innovation Archives - Page 5 of 6

The Future of messenger RNA

Feb 14, 2022Nicholas MitsakosBook Chapter, Life Sciences, Transformative Businessesbiotechnology, cancer, disease therapy, gene therapy, Huntington's disease, innovation, investment strategy, Life-sciences, messenger RNA, moderna, Pfizer, technology, therapies, vaccines

While messenger RNA (mRNA) has been catching recent headlines thanks to its ability to fight Covid, the combination of a global pandemic and the miraculous mRNA vaccine development in less than one year (when typical timelines approach 10 years) has made mRNA life science’s overnight sensation even though the underlying scientific knowledge is based on discoveries from over 20 years ago.

Still, mRNA has the promise to disrupt life sciences and drug development and create enormous economic value. There are fantastic fortunes to be made in mRNA technology. Moderna and BioNTech have created over $100 billion of value collectively, as of February 2022. That kind of value creation will not be ignored by a combination of firms within an industry with hundreds of billions to invest.

There will be an incredible future of development, capital availability, and industry focus until all potential options are exhausted. But, mRNA has a fantastic future, even if it ultimately lives only in labs and R&D centers spread around the globe. It will become an area of focus for every major pharmaceutical company and most biotechs in some form from now on.

Artificial Intelligence and Transformation

Feb 5, 2022Nicholas MitsakosAdvanced Technology, Book Chapter, Transformative BusinessesAdvanced Technology, Artificial Intelligence, computer science, deep mind, innovation, investments, life sciences, Machine learning, protein folding, public policy, technology

Artificial intelligence, while generating powerful tools for analysis, is only the beginning of a more ambitious phase making AI systems more accurate, less biased, and effective prediction tools. Gathering more and more raw data does not create value. One cannot simply push a button and have valuable output generated. Data needs to be collected, processed, stored, managed, analyzed, and visualized – only then can we begin to interpret the results. Each step is challenging, and every step in this cycle requires massive amounts of work and value-added tools. It’s not just the software and hardware artifacts we produce that will be physically present everywhere and touch our lives all the time, it will be the computational concepts we use to approach and solve problems, manage our daily lives, and communicate and interact with other people. It will be a reality when it is so integral to our lives it disappears. The problems and solutions we address are limited only by our own curiosity and creativity.

Web 3.0 Dreams and Reality

Jan 28, 2022Nicholas MitsakosBook Chapter, Investment Strategy, Transformative BusinessesArtificial Intelligence, blockchain, centralization, decentralization, decentralized finance, innovation, investment strategy, investments, technology, valuation, volatility

Every industry consolidates to a handful of centralized competitors. That will never change regardless of current dreams of decentralization from Web 3.0. Modern computing is a constant struggle between decentralization and centralization. Centralization wins eventually, and it will again. These dynamics, combined with the latest crash that may cool investors’ appetite for all things crypto, suggest that Web 3.0 will not dislodge Web 2.0. Instead, the future may belong to a mix of the two, with Web 3.0 occupying certain niches. Whether or not people keep splurging on NFTs, such tokens make a lot of sense in the metaverse, where they could be used to track ownership of digital objects and move them from one virtual world to another. Web 3.0 may also play a role in the creator economy, assuring intellectual property ownership. NFTs make it easier for creators of online content to make money. In this limited way, at least, even the masters of Web 2.0 see the writing on the wall: on January 20th both Meta and Twitter integrated NFTs into their platforms.

what did we learn?

Dec 28, 2021Nicholas MitsakosInvestment Strategy, Prediction, Public Policyinnovation, investment strategy, public policy, risk, technology, volatility

What did we learn this year? Well, not too much. Observing is not learning. Acting is. But we’re not going to do that. A call for action is sufficient, as long as someone else does it. That much we’ve learned. Pandemic Time What used to take several years now takes a fraction of that –…

Digital Assets – Technology of Freedom?

Dec 9, 2021Nicholas MitsakosAdvanced Technology, Book Chapter, Investment Strategy, Transformative BusinessesBitcoin, central banks, Central governments, decentralized finance, digital assets, digital currency, disruption, finance, Freedom, government policy, innovation, investment strategy, public policy, technology, transformation, valuation, volatility

Digital assets are disrupting finance – the world’s largest industry. All assets, intellectual property, and even currency can now be digitized, and anyone can access anything from anywhere. The finance industry is being this intermediated and globalized, economic development and policy will be forever changed.

A Few Simple Conclusions on a Few Simple Topics

Nov 24, 2021Nicholas MitsakosBook Chapter, Inflation, Investment Strategy, Prediction, Transformative Businessescompetition, deflation, inflation, innovation, investment strategy, investments, moat, monopoly, public policy, sustainability, technology, transformation, transformative businesses, valuation, volatility

Transformation, Valuation, Employment, and Deflation

Disruption to some of the world’s most important industries, deflationary pressure caused by scaling lower-cost businesses, and sustained low interest rates challenge traditional valuation models. Technological platforms, from blockchain-based businesses to energy storage to DNA sequencing, enable unprecedented disruption to business and economic models.

Interest rates will remain low, equity values will remain high, innovation will drive deflationary pressure, and volatility will be intense and frequent. A new approach is required to understand dynamic global competition and sustainable value.

Failures are not Failure

Oct 29, 2021Nicholas MitsakosBook Chapter, Investment Strategycreativity, failure, fortitude, innovation, risk, success, volatility

Failures are essential for success. The NASA flight director, Gene Kranz, who is famous for the Apollo 13 quote, “Failure is not an option” has been misunderstood. Mr. Kranz did not mean “don’t fail.” He meant was that there will be a solution, think boldly and courageously because, while the solution may not be obvious to you now, you will find it eventually.

Accepting failures is not accepting failure.

Failures – trial and error, unforeseen roadblocks, creative thinking, visions, and revisions that a minute will reverse – lead to insight, innovation, creativity, and unforeseen breakthroughs. That’s success.

Failure is when you stop.

Life Sciences: The Real, the Hoped, and the Hyped

Sep 9, 2021Nicholas MitsakosBook Chapter, Investment Strategy, Life SciencesBiotech, biotechnology, gene therapy, hype, innovation, investment strategy, investments, life sciences

Investors have been swept up in the notion of “philanthropic capitalism” and have targeted life-sciences as an avenue that can fulfill this benefit to society. While laudable in concept, this is non-scientific surrealism. “Hoped-for” is not a reliable business model, and most of the unrealistic goals would not be sustainable even if achieved. Real science and innovation are more impactful and substantial and make life sciences even more.

TECH Policy and Unintended Consequences

Aug 17, 2021Nicholas MitsakosAdvanced Technology, Book Chapter, Investment Strategy, Public PolicyArtificial Intelligence, central government, central planning, china, cloud computing, creativity, industrial policy, innovation, investment strategy, investments, public policy, quantum computing, semi conductors, socialism, technology, US, volatility, Western Europe

Technology is facing a substantial crossroads as policy changes with global resonance, such as China’s new crackdown on the country’s big tech companies (such as Ant Financial and Didi Global), the rising resistance to social media behemoths like Facebook, and the need for governments, whether in the United States, Western Europe, or China, to manage and control technological development. Regardless of any good intentions, this will add friction, inefficiency, and underperformance to the most dynamic global industry. The best intentions usually bring disastrous consequences. China cannot escape the law of unintended consequences. Trying to “manage” innovation and creativity takes away the often unplanned and serendipitous breakthroughs that make many significant advancements possible in the first place. From an economic perspective, capital is not going to invest in an uncertain environment where prosperity is managed and, despite great risk where most ventures will fail, the truly successful ones which make up for the losses and encourage capital to keep investing, will be mitigated. The vanguard of capital flight from China is beginning, and it will not ease if this policy and attitude are not revised. This attempt at “fairness and more equal distribution” will do nothing more than keep capital away and stifle any attempt at creativity, technical innovation, and economic advancement. The intention of this policy will yield the opposite outcome as a consequence. The signal means substance. Substance means innovation, creativity, and competitive dynamics that create the most effective innovations, the best solutions, and the most sustainable companies. Central planning, bureaucratic industrial policy, government-led economic management, and dictatorial focus have always failed, and always will. The US should not fall into this trap, regardless of how appealing it may be.

It is only noise.

Time to Worry

Feb 23, 2021MitsakosBook ChapterBitcoin, crypto, innovation, investing, long-term investing, risk, stock market, technology, trading platform, volatility

When Everything is Going Great, It Probably Isn’t.

Things can only get better from here… said the turkey the day before Thanksgiving. It’s challenging to know when it’s too late because things go badly gradually, then suddenly.

It might be time to start worrying about tech-stock valuations. Usually, all it takes is a few overly ebullient stock analysts to set off an alarm. When unreasonableness takes over (remember all those analysts’ reports from March 2000? The NASDAQ could only go up and all those internet funds were going to double again in 2001?). In March 2000, the bellwether for this nonsense was Henry Blodget’s recommendation of Amazon with a target price of $400.00 by March 2001 (at the time Amazon was trading for about $60.00 a share). Instead of being $400.00 in March 2001, Amazon’s price was $5.97 per share.

Long Term Value Means Long Term

Of course, Amazon has created an amazing business model and is fundamentally rewriting technology services and customer logistics. Trading at almost 100 times earnings the market believes there is much more growth and profitability to come. Really? Regardless of your perspective about that, Amazon is an example of investments that are either “don’t bother it’s ridiculous” or “never sell it’s ridiculous.”

The market may stay permanently irrational about companies like Amazon, or Amazon may catch up to the market’s irrationality. What should an investor do? The answer is simple – don’t play. By that I mean you either buy the stock and ride the tiger (which means you can never get off – or sell) or stay out of the jungle completely – don’t ever buy. Half measures rarely have good outcomes.

Amazon is exemplary. This tiger has rallied substantially since those woeful days in March 2001 to close above $3,200 per share in February 2021. So, even if you listened to the absurdity belched out in March 2000, and on paper, had substantial losses from your Amazon investment for several years, if you held on, you are brilliant and rich (more like lucky; but it’s smarter to be lucky than lucky to be smart). Don’t listen to the analysts and don’t get off.

Nicholas Mitsakos

Investor, Entrepreneur, Writer, and Lecturer