Globalization Under Threat 

The paranoia is building. From the CHIPS Act to proposals for absurdly high tariffs (60% on goods from China isn’t going to help anyone) to banning TikTok, the world is on the verge of reversing decades of progress and exchanging real progress for delusionary gains.
Efforts to localize production and economic development with vast government subsidies are being proposed or enacted in the United States, the EU, China, India, and any other economic center that can think of it.
Hiding behind walls has never worked and makes life worse for everyone.

The AI Horizon

Artificial intelligence is poised to significantly impact various fields and activities, transforming how we approach creativity, professional activities, science, and many more domains. Disruption will accelerate the development of new innovative businesses and strategies in finance, medicine, data management, systems engineering, materials science, art, and other industries. AI’s impact will be profound and multifaceted, driving innovation and efficiency and posing challenges regarding ethics, job displacement, and new skills and regulations. As AI continues to evolve, its integration into these areas will likely shape the future of human society in significant ways.

A Golden Age of Miraculous Cures…Perhaps

The first gene-edited approved drug (treating sickle cell anemia) is the first commercial rewriting of human genomes. Is this a new “Golden Age” for medicine? There is great promise, and the potential to treat unmet medical needs, scale dramatic innovations to commercial applications, and transform life sciences is enormous. Since every medicine is an intersection of scientific, technical, and clinical understanding, many new treatments are suddenly arriving because of the convergence of dramatic advancements in science, technical knowledge, and clinical results. Modern medicine is witnessing a transformative era of groundbreaking innovations and technological advancements. We are witnessing a renaissance in drug treatment driven by innovations in immunotherapy, weight management, vaccine development, gene editing, and AI. These advances reshape medical treatments and fundamentally alter our approach to health and disease. As these technologies mature and their applications broaden, the future of medicine holds unprecedented potential for improving human health and longevity. A golden age – with a bit of hype.

An Optimist’s Vision of AI

The era of artificial intelligence is here, and it’s generating despair and fear over the loss of control and the worry that artificial intelligence is about to unleash killer robots and enslave humanity. Perhaps…or, something else. Artificial intelligence will improve lives and generate greater access to education, improve healthcare, and advance climate science. Among many other improvements, AI’s benefits greatly outweigh its costs. AI has its costs since everything comes with a price (there are always both sides to the ledger), but the extraordinary benefits that artificial intelligence can unleash are worth the effort. Don’t slow down, pause, or restrict research, development, and AI applications. Prometheus gave the world fire and while we can still cause great harm, it was among the single greatest advancements for humankind. Artificial intelligence can be the same thing for our modern-day recipients of fire from the gods. But, we can’t be naïve. We can still burn the earth down if we are not careful.

AI will not destroy the world – and is more likely to save it. I’s trajectory points towards a future where it not only enhances technological capabilities but also enriches human lives. Its evolving role will be characterized by a synergy between human and artificial intelligence, propelling societal progress and opening new frontiers of innovation and discovery is not just a technological advancement; it’s a catalyst for a new era of human endeavor.

Its impact is vast, touching every aspect of our lives and work. As AI continues to evolve, its role in shaping our society and driving innovation will only become more significant, opening new horizons for growth, creativity, and human potential.

Cryptocurrency and Digital Assets: Terror and Opportunity

Cryptocurrencies soar in value, plunge, hit new highs, are written off, rebound, and hit new highs again, and the cycle repeats. We should be terrified. Over the last five years, cryptocurrencies such as Bitcoin and Ether have outperformed the overall market. However, can the general trend of outperformance last, or will these digital assets drop over 90% like some of its other crypto brethren? Is there a sustainable performance that creates the foundation for either a new currency or a valuable asset class? Probably not. Forces that drive these eye-watering returns seem to be the same as those that drove the social media-driven insanity behind meme stocks such as GameStop. We are seeing social media mobs controlling demand to a limited supply, creating price spikes that look attractive to any speculative investor. Unfortunately, demand can dry up quickly and the price subsequently falls through the floor. Financial markets ruthlessly sort nonsense from substance. Volatility and existential threats have been brutal and extreme for digital assets and the reckoning for crypto has been predicted for some time. However, digital assets are not on their way to history’s dustbin. Reality is more nuanced, and I try to provide a more detailed analysis since a broad brush hardly seems appropriate. The weakest and craziest portions of the crypto world have been exposed as nothing more than silliness. But some valuable components remain resilient and offer tremendous opportunity. I will explore these in detail. There is more cause for optimism than pessimism among the best and the brightest. We will explore these opportunities while harshly dismissing the hype and silliness – avoid the terror of a worthless market.

Today, Tomorrow, and the Apocalypse

The future does not need us, and apparently, we don’t need it either.

The future isn’t what it used to be.

Humankind evolved to have a long-term view, either from religious teachings, the seasons, empires, and epoques, beyond the temporal spaces of our lifetimes. We went from living in an extended present to thinking about a long-term future.

Our horizons have gotten much shorter. When I wrote my latest book, “The Ten Year Horizon,” ten years seemed a sufficient and faraway temporal space to discuss a long arc of basic scientific research and discovery that could address our most urgent problems. However, it’s most appropriate to think a century ahead in order to understand the future we really want. It’s not just for us, it’s for generations to come.

Collectively, mankind has never had so many ways to destroy itself through self-made dangers including nuclear weapons, bioterrorism, climate change, antibiotic resistance, and many other self-manufactured threats. It is time for temporal maturity and ignore the tumultuous waves striking the boat today and keep our eye on the long-term horizon.

Short-term thinking has brought the potential for a catastrophic crisis even closer. Perhaps now it is time to grow up and think about the future. What do we want to be – because whatever that may be, we are certainly not working towards it now.

Conservation Won’t Work

In crisis there is opportunity. The infrastructure of modern society – utilities, telecom systems, energy systems, highways, and other components – is essential for global economic development, unavoidable, demanded by many, pose insurmountable obstacles, and is poised at the edge of transformational change. They Want What We Have Emerging economies need a range of basic

Put Down the Pitchforks

Stunning capabilities are emerging from large language models like GPT 4 that, until very recently, were thought to be only theoretical. We could never have the data sets or the processing power to generate real and usable results. Well, all that has changed – rather suddenly.

But is it time for the torches and pitchforks? What are the serious risks that accompany this technology?

There will be good and bad, like every new era. Will it be the Middle Ages all over again and we’ll experience The Plague before the Renaissance, or will it be more balanced and reasonable? There are good, bad, and many things in between whenever humanity advances.

Let it happen. Put down the pitchforks.

Globalization and Optimism

Isolationism, fragmentation, and pessimism always fail. Globalization has been everyone’s favorite punching bag for a while. It is hard to feel optimistic about its prospects. However, globalization has a better future. If you are a fan of globalization, cooperation, and comparative advantage, the last decade has been extremely challenging. Ten years ago was a time of optimism on a global scale. However, economic and geopolitical forces have combined to add friction and fragmentation to global exchange. The benefits are now even greater and with everyone’s self-interest and mutual benefit, this geopolitical stalemate will pass – more quickly than is commonly thought today. Cooperation, integration, and mutual benefit win in the end. It is time to be optimistic once again.

Discovery, Innovation, and Crisis

Our most intractable problems cannot be solved with behavior modification, conservation, or our existing technology, regardless of its advanced or widespread applications.

Only new knowledge creating innovative solutions can address our most intractable problems. This can only be achieved through basic scientific discoveries and then combining these discoveries with enterprise-based innovation, commercial discipline, and competition. Innovation, creativity, and competitive dynamics create the most effective innovations, the best solutions, and the most sustainable companies. Developing the best public policy as well as the best structure to enable innovative and creative solutions, as well as the economic incentive to scale these opportunities and make them economically sustainable.

Central planning, bureaucratic industrial policy, government-led economic management, and dictatorial focus have always failed, and always will.